Tory MP Miriam Cates highlights the "inevitable harms" from additional restrictions, including the increased risk of domestic violence from home working.
She argues mandatory masks also send a signal "to panic", with some schools already closing early for the holidays.
She opposes Covid passes, describing them as "discriminatory" and segregating people.
Cates says the measures reflect a "permanent change to the understanding of what liberty is in this country" as she calls for a return to a society of "freedom and responsibility".
In a pantomime-style performance, Tory MP Richard Drax lists the reasons he opposes the additional measures.
"Do we want new restrictions every time a new variant appears?" he asks.
No, is the response from many of his fellow MPs.
Do we want to see the hospitality and retail sector collapse because we're instilling the fear of GHod into their customers? No, is their response.
He finishes his speech by saying it is "time to put fear to one side, put our shoulders back and get on with our lives".
Tory MPs continue to line up against some of the measures and next up is Anthony Mangnall.
He says he will oppose the extension of mandatory masks, Covid passes and mandatory vaccination for NHS staff.
He argues the legislation on masks is "shoddy" and points out inconsistencies, such as colleagues being able to sing or eat together but not go to work.
Mangnall says there is also little evidence to show Covid passes work.
"We cannot continue to terrify people," he tells the Commons, saying he is "staggered" by how the government has used fear to try to persuade people in the past two weeks.
Conservative Derek Thomas says is worried that the NHS and government are too focused on Covid, rather than other "severe difficulties" many people are facing with their health.
The MP for St Ives says he believes the government's imposition of restrictions to fight the virus has caused people to miss out on treatment they need from the health service.
He asks: "How many more cancer patients will miss their diagnosis and treatment and lose their lives because we told them to protect the NHS?"
Thomas adds the government should reopen the emergency Nightingale hospitals to "deal with Omicron and protect the NHS".
He adds he will be supporting the government on booster jabs and testing, but will oppose all other measures.
Tory MP Greg Smith says he won't vote for the extension of mandatory masks, Covid passes or mandatory vaccination for NHS staff.
He argues the measures are a "slippery slope" and not without harm, including damage to the economy.
He also gives the example of people who may be unable to wear a mask or deaf people not being to lip read a mask-wearer.
Smith says the government should focus on the booster rollout and otherwise "give people their freedom back to choose".
Former minister Andrea Leadsom says she will not support compulsory vaccination for NHS staff, saying daily testing as an alternative would be a "practical and fair solution".
It would also avoid the risk of losing those NHS and care staff who are unwilling to be vaccinated, she adds.
On measures like Covid passes, she says the focus should be on persuading people to get vaccinated, rather than "criminalising" them.
She argues the measures being proposed by the government are "precautionary" and asks why the quality of life of citizens should be limited "just to be on the safe side".