well unless Dier and Dembele form really drops I cant see Wanyama replacing them and cant see Jansen starting over Kane unless his form drops, not trying to be negative, just think with the champs league and not being able to rest players as much on the wed and then needing them again on the sat will be lots of game time for the strongest 11 which I dont feel has changed from the first 11 that finished last season
I think you will see something like what you saw with Walker/Rose & Trippier/Davies for Waynama & Jansen, additionally both of them will allow Kane/Dier/Dembele to get taken off 10-20 minutes from end in games we are comfortable in.
I don't see us rotating heavily in PL & CL, but do think the FA/CC cups will see a 2nd team.
Only teams that can afford to pay people 120K+ to sit on the bench can rotate as heavily as you are thinking.