I've always maintained that it's not the first 70 minutes of a match that brings on the fatigue, but rather the last 20 (or 25 including injury time). That's why I was glad to see Poch's subs against Swansea -- we were in control, so time to take off some key players. That's how Fergie managed his ManU teams through the season -- of course, you can't do it if you've not got a two-goal cushion!
It's not necessarily predictable how knackered each player is, as it depends on style and position as well as each player's inherent fitness and profile. But I do think Eriksen and Kane are looking tired. Defensively, perhaps Verts is mentally fatigued -- I would play Verts + Fazio for this one, so that Fazio can take some of the organisational burden.
In midfield, Mason keeps his place. Not sure about Bentaleb, but reckon he should play the first 60 minutes then, all being well, be subbed off for Stambouli. Chadli stays, and we have no choice but to play Kane. Start with Lamela too, with a sub for Eriksen on the cards.
Starting:
----------------- Lloris -----------------
Walker -- Fazio -- Verts --- Rose
-------- Mason ----- Bentaleb ------
Lamela ---- Dembele ---- Chadli
----------------- Kane -----------------
Finishing (if all goes to plan):
----------------- Lloris -----------------
Walker -- Fazio -- Verts --- Rose
------- Mason ------ Stambouli ----
Eriksen ---- Dembele ---- Chadli
--------------- Soldado ----------------
COYS!