Depends, there is a big myth on this board that if a manager fails somewhere, their "shot" at big time is gone. Football managers fail ALL the time, the nature of the job is you will be fired (Ancelotti quote "I've been fired from every job I've ever had")
Doesn't mean you will take any job, but if the money is right, most managers will take a punt (Ancelotti at Everton was perfect example, £11M/yr, achieve fudge all, still go on to get Madrid role)
I genuinely think something like United is more of poisoned chalice than us, here the blame will go to club structure/ownership and you can point to Poch/Jose as other "top" managers who struggled here.