That is the million dollar question. Ironically, this squad lends itself well to the prior managers' tactics. You could see Conte's 3-5-2 (Serie A) or 3-4-3 (PL) working with this set of players. Jose's 4-3-3 was way too deep but he would have moved that back line up once he got the pace into the back four. Your point is well made about the press as under Jose the gap between midfield and the forwards was a chasm. It was our downfall. Then you look at Poch's 4-2-3-1, suiting guys like Madds, Kulu and Bergval in a flexible 3 with the fullbacks wide.
If I were Ange, I wouldn't get the full-backs becoming midfielders every single time. It becomes predictable. When Pep brought that to us with Cancelo it was the surprise factor that made the difference. So I would adapt that along with just bringing the defensive line back a little. Still stay on the press but start to make sure we play with a number 6. It doesn't have to be the same person, but we can't have situations where both the double pivot our out of the game on the press. Perhaps more like Klopp's team when they had Fabinho as the holder. They still hounded you all over the park.
Perhaps, Ange could adapt to a system where the full-back can be wide and the winger goes narrow or vice versa. Anything that keeps the opposition guessing. I'd also like to see those wide players switching sides more.
The other big area is set piece defending. I haven't studied it yet this season, but last season we had 3 big men on the 6 yard line marking nobody and the rest as blockers. It didn't work, especially not having any Spurs player in with our keeper. I'm waiting to see whether that structure has evolved so we don't end up with relegation stats for set piece defending again.