Is it because you are that much more wise about the teams of the higher leagues? If so, and if you plan to make money off the lower leagues, why not put in a bit of time getting to know the lower leagues and the teams involved? That way, you will have a better chance of making profits. Plus, I think the lower leagues are likely where more value is held as the bookies are less aware of the teams involved too. Plus, punters will often go for the favourites when some of the favourites may be priced up incorrectly thanks to information that others don't know, but that you could know if you studied the teams more.
I'm going to put in some effort studying, see whether it helps out as other than knowing Wolves are strong and usually priced at at least evens, which is great considering how good they are, and MK Dons are usually both teams to score, I don't know very much else.