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  1. M

    Mauricio Pochettino - Sacked

    Would absolutely agree with that. I'm fine with it too.
  2. M

    Mauricio Pochettino - Sacked

    There's not a manager on the planet that would rather his team conceded a free kick than won the ball back whether that is higher up the pitch or anywhere else. Who has suggested that Poch's game plan is a cynical plan to kick teams off the pitch or that the high number of fouls is anything...
  3. M

    Quacks & Pseudoscience

    I think to a large extent they dropped the ball on homeopathy as it had such a small impact until relatively recently when there was a pretty explosive growth in the industry. That's the FDA party line anyway, again I've no experience in homeopathic medicines either (thankfully) so can't really...
  4. M

    Mousa Dembele

    Yeh it was a hip issue. Might be related, might not. We'll probably never know, but hopefully it doesn't keep him out long.
  5. M

    Quacks & Pseudoscience

    I'm saying if they were willing to play with patient safety through running purposefully flawed clinical studies they would not get that past FDA or IRB. I genuinely don't feel that there is a trend in the Pharma industry to try and 'fix' clinical study results in their favour using unethical...
  6. M

    Quacks & Pseudoscience

    Most of these are for off-label promotion which I'm sure you know is where sales reps promote their products for uses not approved by FDA. So we can rule any mal-practice by FDA out. It also occurs post approval, and as I keep saying, in order to get approval you have to submit clinical...
  7. M

    Quacks & Pseudoscience

    I have access to clinical protocols, manufacturing batch records, INDs, CoAs, stability data, basically everything that is required for the release of a clinical batch (for both active drug and placebo). I have enough confidence in my own understanding to believe that if the setup of a clinical...
  8. M

    Mousa Dembele

    I was saying Mason was the better option. Not sure if you were aiming your post at me having mis-read my post or agreeing with me having read it correctly.
  9. M

    Quacks & Pseudoscience

    I disagree. I think it's important in any critical text to at least mention the other side of the argument. Then come to a conclusion and explain why you sit on the other side. He's almost done what he accuses the Pharma industry of doing, only instead of only presenting the good things, he...
  10. M

    Mousa Dembele

    Mason was the better option at the time, because he moved the ball more quickly in a system that required people to move the ball quickly. Now Dembele is moving the ball more quickly but still has the added attributes that we all no he has. So Dembele is now the better option.
  11. M

    Quacks & Pseudoscience

    Not just smarter (they may or may not be), but often better equipped, with more experience, more resources and more support. Of course as you say this is just one of many factors, but he only mentions the unethical factors that may or may not be in play. I see this as a little unfair and...
  12. M

    Quacks & Pseudoscience

    Had a bit more of a read of the article, although I'd probably need to read it another 2 or 3 times to take in all the info. He's left out some pretty key information on the TGN1412 study. I don't agree with his conclusion that had the results been published that the 2006 study would not have...
  13. M

    Quacks & Pseudoscience

    I've not read the book (I'd like to though, if I ever find the time). I skim read the article. I'd like to see more detail on the types of trial that are being run by industry verses non industry. My inclination is that they are likely to be very different. However, considering Ben Goldacre...
  14. M

    Quacks & Pseudoscience

    How about for a known chemical entity that is going to be marketed for a new illness? At minimum you'd need to go back into Phase 3, which would mean you'd need a repeat end of Phase 2 meeting with FDA. As part of the meeting package you'd detail that you want to go for a new indication. The...
  15. M

    Quacks & Pseudoscience

    It depends on the type of drug and is all based on the risk to safety of the patient. One clinical trial is enough for a bioequivalence study where you're taking a reference drug that is already on the market and all you have to show is that blood levels are equal to that of the reference drug...
  16. M

    Quacks & Pseudoscience

    I work in R&D for a drug company. Some stuff in that has been mentioned is correct, some stuff is nonsense. Bottom line, I'm with @scaramanga. A drug company can't market a drug without showing through one or a number of correctly powered clinical studies that the drug works better than...
  17. M

    Mauricio Pochettino - Sacked

    One of the things I've been very much impressed by Poch is something that also used to really impress me about Fergie. Fergie used to change the united team about, slot players in and out yet never seemed to see a drop in performance. If you look at some of the squad players he had over the...
  18. M

    RIP David Bowie

    Yeh, I thought the Gaga thing was crass as fudge. Something more subdued would have been much nicer.
  19. M

    I liked Erik Lamela before it was cool

    I actually quite like that he went for the time wasting option, not because it was necessarily the right thing to do, but it shows a team mentality. He put the benefit of the team in front of his own glory. Yes, yes, I know, I know if he had of scored this would have benefited the team more...
  20. M

    The Spanish Football Thread

    Neymar has apparently said that it was meant to go to him but Suarez nipped in first.
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