Tottenham Hotspur host Manchester United at White Hart Lane on Sunday 4th March 2012 in the 27th round of matches in the 2011-12 season.
Spurs come into the match in 3rd place on 53 points with United one place above Spurs in 2nd place on 61 points.
It will be the 181st meeting between the two clubs who were the "glamour teams" of the 1960s.
Tottenham Hotspur's first meeting with Manchester United came in the old 1st round (today's 3rd round) of the FA Cup in January 1899 when United were known as Newton Heath. The match was drawn 1-1 at Northumberland Park, but Spurs won the replay 5-3 at Bank Street in Clayton, Manchester.
A decade later the two clubs met for the first time in a Football League match with United drawing 2-2 at White Hart Lane in the First Division.
The reverse fixture at Old Trafford was easilly won by United 5-0.
Tottenham's first League win over United came in November 1911 2-1 at Old Trafford.
Both clubs met for four seasons in the Second Division during the 1930s.
Since the start of football after WW2, all League meetings have taken place in the Top Flight of the English League system.
In 1952, both clubs toured North America and played two exhibition matches with Spurs winning 5-0 in Toronto, Canada and 7-1 in New York, USA.
The clubs were drawn together in the 1963-64 European Cup Winners' Cup with Spurs winning 2-0 at the Lane and United winning 4-1 at Old Trafford.
Old Trafford was the venue for the 1967 FA Charity Shield with League Champions United and FA Cup Winners Spurs drawing 3-3 in a game most remembered for goalkeeper Pat Jennings' long-range goal. The Charity Shield was shared.
August 1979 saw the clubs meet for the first time in the Football League Cup and Glenn Hoddle's magnificent volly was the winning goal in a 2-1 Spurs victory at White Hart Lane. United went on to win the second leg at Old Trafford 3-1.
In June 1983, the clubs played two matches in Swaziland, Southern Africa, resulting in a win each.
The clubs have only ever met in one Domestic Cup Final - the 2009 Football League (Carling) Cup Final at Wembley, which ended in a 0-0 draw after extra time. United won the subsequent penalty shoot-out.
Manchester United and Tottenham Hotspur were founder members of the Premier League in 1992-93 and are two of the seven clubs who have been ever-present up to the 2011-12 season - Arsenal, Aston Villa, Chelsea, Everton and Liverpool being the other five.
The fixtures during season 2010-11 saw United win 2-0 at Old Trafford in October while the reverse match at White Hart Lane ended in a 0-0 draw.
2010-11 was the first season when both Manchester United and Tottenham Hotspur competed together in the UEFA Champions League. Both clubs won their respective Group Stages and progressed to the Knock-Out Phase. Spurs eventually went out to Real Madrid in the Quarter Finals while Manchester United made it to the Final, only to lose to Barcelona.
The reverse fixture at Old Trafford earlier this season in August resulted in a 3-0 win for United with goals from Danny Welbeck, who headed in Tom Cleverley's cross just after 60 minutes and he then produced a wonderful instinctive flick to set up a second for Anderson. Wayne Rooney scored with a pinpoint late header from Ryan Giggs's centre.
Spurs signed former United striker Louis Saha during the January transfer window and he has scored three Premier League goals in his three matches in Tottenham's colours.
Overall, United have a very good record over Spurs with 85 wins to 49 with 46 of the 180 matches played so far drawn.
Jamie Attwell
David Beckham (United player, Spurs trainee)
Dimitar Berbatov
Bill Berry
Alan Brazil
Jimmy Brown
Fraizer Campbell
Michael Carrick
Garth Crooks
Harry Erentz
Quinton Fortune
Terry Gibson
Tommy Gipps
Greoge Graham (United player, Spurs manager)
Jack Hall
Stewart Houston (Uunited player, Spurs asst. manager)
David Gwilan Jones
Joe Jordan (United player, Spurs coach)
Cyril Knowles
Chris McGrath
James McNaught
Fred Milnes
Louis Saha
Teddy Sheringham