Kevin Danso is still “weeks away” from a return from a toe injury, so Radu Dragusin could make his first start in over a year.
Djed Spence is fit to return after two games out with a calf injury, in some good news for Spurs ahead what feels like another big game for Thomas Frank.
Frank said: "We lose two players but we get Spence back and I think Dragusin looked good when he came back in, so I know we will put a very competitive team out tomorrow as well."
On Danso, Frank said: “He met the consultant. It's going forward, but it's still weeks before he's available.”
With Spence and Brazilian left-back Souza fit and available, Frank could opt to revert to a three-man defence after utilising a 4-3-3 against United.
However, with Souza yet to start since signing from Santos for £13million in January, Frank is likely to play Spence at left-back and Archie Gray at right-back.
After the United defeat, Spurs are now just six points from the relegation zone and are still searching for their first league win of 2026.
Tottenham predicted XI (4-3-3): Vicario, Gray, Dragusin, Van de Ven, Spence, Gallagher, Palhinha, Sarr, Odobert, Solanke, Simons