Kane was completely gassed past 75 - bring him off, bring Janssen on to stick out his a*se and keep possession in the corner.
KWP - bring him on to sit ahead of Trippier, who cannot defend to save his life, and provide some full-back cover.
Winks - bring him on earlier. 75th minute, maybe. Dembele was hobbling around on one leg near the end, why Winks was held back until six-odd minutes before the end is beyond me.
Dao Sanchez - send him on earlier as a quick, warm body to shore up the back three, if necessary.
Or bring on two players at once in the 75th minute - or three players in the 80th, or *something* similar to show the team that sleepwalking into an inevitable f*cking goal conceded isn't on.