FC Midtjylland 1 - 1 (2-1 agg) Videoton FC
HJK 0 - 2 (2-3 agg) IFK Gothenburg
Nomme JK Kalju 0 - 2 (0-3 agg) Osmanlispor FK
FC Krasnodar 3 - 1 (6-1 agg) Birkirkara
Spartak Moscow 0 - 1 (1-2 agg) AEK Larnaca
Spartak Trnava 0 - 1 (1-1 agg) Austria Wien (Austria through on penalties)
AIK 0 - 2 (0-3 agg) Panathinaikos
Arouca 0 - 0 (1-1 agg) Heracles (Arouca through on away goals)
Beitar Jerusalem 3 - 0 (4-1 agg) FK Jelgava
FK Qabala 1 - 0 (2-1 agg) Lille
Mlada Boleslav 1 - 0 (1-2 agg) KF Shkendija
PAS Giannina 1 - 2 (1-3 agg) AZ Alkmaar
Vorskla 2 - 3 (2-3 agg) NK Lokomotiva
SoenderjyskE 1 - 1 (3-2 agg) Zaglebie Lubin
Maccabi Tel Aviv 2 - 1 (5-2 agg) Pandurii
Apollon Limassol 3 - 3 (4-5 agg) Grasshopper (Grasshopper through on away goals)
Dinamo Minsk 0 - 2 (1-3 agg) Vojvodina
AEK Athens 0 - 1 (0-1 agg) Saint-Etienne
Brøndby IF 3 - 1 (3-2 agg) Hertha Berlin
FC Viitorul Constanta 0 - 0 (0-5 agg) Gent
Maribor 1 - 0 (2-1 agg) Aberdeen
Rijeka 2 - 2 (2-2 agg) Istanbul Basaksehir (Istanbul through on away goals)
Hajduk Split 3 - 1 (6-1 agg) FC Olexandria
Sassuolo 3 - 0 (4-1 agg) Luzern
Cork City 1 - 2 (0-3 agg) Genk
West Ham United 3 - 0 (4-2 agg) Domzale
Rio Ave 1 - 1 (1-1 agg) Slavia Praha (Slavia through on away goals)
Rapid Wien 3 - 0 (3-0 agg) Torpedo Zhodino
Playoff round:
Seeded teams: Shaktar Donetsk, Olympiakos, Anderlecht, AZ Alkmaar, Fenerbache, Sparta Praha, PAOK, Genk, BATE Borisov, Saint-Etienne, Gent, Krasnodar, Rapid Wien, Slovan Liberec, Maribor, Maccabi Tel Aviv, Austria Wien, West Ham, Panathinaikos, FC Midtjylland, Sassuolo, Garabag Agdam
Unseeded teams: Rosenborg, FK Astana, Astra Giurgiu, Hajduk Split, Arouca, Grasshopper, AEK Larnaca, Vojvodina, Istanbul Basaksehir, Brøndby, Crvena Zvezda, Osmanlispor, Slavia Praha, IFK Göteborg, Dinamo Tbilisi, Lokomotiva Zagreb, AS Trencin, FK Qabala , Beitar Jerusalem, SonderjyskE, Shkendija Tetovo, Partizani Tirana
HJK 0 - 2 (2-3 agg) IFK Gothenburg
Nomme JK Kalju 0 - 2 (0-3 agg) Osmanlispor FK
FC Krasnodar 3 - 1 (6-1 agg) Birkirkara
Spartak Moscow 0 - 1 (1-2 agg) AEK Larnaca
Spartak Trnava 0 - 1 (1-1 agg) Austria Wien (Austria through on penalties)
AIK 0 - 2 (0-3 agg) Panathinaikos
Arouca 0 - 0 (1-1 agg) Heracles (Arouca through on away goals)
Beitar Jerusalem 3 - 0 (4-1 agg) FK Jelgava
FK Qabala 1 - 0 (2-1 agg) Lille
Mlada Boleslav 1 - 0 (1-2 agg) KF Shkendija
PAS Giannina 1 - 2 (1-3 agg) AZ Alkmaar
Vorskla 2 - 3 (2-3 agg) NK Lokomotiva
SoenderjyskE 1 - 1 (3-2 agg) Zaglebie Lubin
Maccabi Tel Aviv 2 - 1 (5-2 agg) Pandurii
Apollon Limassol 3 - 3 (4-5 agg) Grasshopper (Grasshopper through on away goals)
Dinamo Minsk 0 - 2 (1-3 agg) Vojvodina
AEK Athens 0 - 1 (0-1 agg) Saint-Etienne
Brøndby IF 3 - 1 (3-2 agg) Hertha Berlin
FC Viitorul Constanta 0 - 0 (0-5 agg) Gent
Maribor 1 - 0 (2-1 agg) Aberdeen
Rijeka 2 - 2 (2-2 agg) Istanbul Basaksehir (Istanbul through on away goals)
Hajduk Split 3 - 1 (6-1 agg) FC Olexandria
Sassuolo 3 - 0 (4-1 agg) Luzern
Cork City 1 - 2 (0-3 agg) Genk
West Ham United 3 - 0 (4-2 agg) Domzale
Rio Ave 1 - 1 (1-1 agg) Slavia Praha (Slavia through on away goals)
Rapid Wien 3 - 0 (3-0 agg) Torpedo Zhodino
Playoff round:
Seeded teams: Shaktar Donetsk, Olympiakos, Anderlecht, AZ Alkmaar, Fenerbache, Sparta Praha, PAOK, Genk, BATE Borisov, Saint-Etienne, Gent, Krasnodar, Rapid Wien, Slovan Liberec, Maribor, Maccabi Tel Aviv, Austria Wien, West Ham, Panathinaikos, FC Midtjylland, Sassuolo, Garabag Agdam
Unseeded teams: Rosenborg, FK Astana, Astra Giurgiu, Hajduk Split, Arouca, Grasshopper, AEK Larnaca, Vojvodina, Istanbul Basaksehir, Brøndby, Crvena Zvezda, Osmanlispor, Slavia Praha, IFK Göteborg, Dinamo Tbilisi, Lokomotiva Zagreb, AS Trencin, FK Qabala , Beitar Jerusalem, SonderjyskE, Shkendija Tetovo, Partizani Tirana