Ange has a squad of imo around 19 players Ange "trusts" - trusts enough to start in the PL.
Vicario, Forster, Porro, Romero, Dragusin, VdV, Davies, Udogie, Bissouma, Bentancur, Sarr, Maddison, Kulusevski, Johnson, Odobert, Solanke, Richarlison, Son, Werner.
We then have around 5 players that Ange doesn't quite trust as much. Or perhaps players he's close to trusting to that kind of level, but not quite there yet.
Spence, Gray, Bergvall, Moore, Lankshear.
2-3 players missing and we're probably mostly going to be fine. And still have good enough options on the bench, some ability to rotate. But recently we've had too many players missing at the same time to meaningfully rotate well, have suffered through fatigue and some lack of quality as a result of starters missing (though no one individual squad player has been bad as such).
The plan must be to get to 23-25 players Ange (or whoever is in charge trusts sufficiently). Until such a time injury issues like we've had now, combined with fixture congestion, will always be really difficult to deal with.
We're moving in that direction, but through a more medium term plan focusing on younger players. I'm fine with that and hope Ange gets the time to get there.